夏娟
教授
博士生導師
碩士生導師
導師簡介
【學位 / 學歷】
博士 / 博士研究生
【學術簡歷】
1993.09-1998.06 ?四川大學口腔醫(yī)學專業(yè)獲碩士學位
1998.09-2001.06 ?四川大學口腔醫(yī)學專業(yè)獲碩士學位
2001.09-2004.06 ?四川大學臨床口腔醫(yī)學專業(yè)獲博士學位
【研究方向】
1.口腔黏膜病的發(fā)病機制、防治與康復新策略
2.口腔軟硬組織缺損修復的新技術研發(fā)
【主持課題】
1.?2024-2027年：《放射誘導 POSTN+ 成纖維細胞活化擾動口腔黏膜細胞外基質穩(wěn)態(tài)促進黏膜下纖維化的作用與機制研究》，國家自然科學基金區(qū)域創(chuàng)新發(fā)展聯合基金重點支持項目，260萬
2.?2022-2025年：《口腔角質形成細胞焦亡激活NF-κB-OPA1通路參與口腔扁平苔蘚T細胞糖代謝重編程的機制研究》，國家自然科學基金面上項目，52萬
3.?2019-2022年：《組蛋白乙酰化修飾調控miR-1181-SOX2軸在口腔白斑病發(fā)生發(fā)展中的作用及機制研究》，國家自然科學基金面上項目，57萬
4.?2018-2021年：《Twist1調控上皮細胞可塑性在口腔黏膜癌前病變演進中的作用與防治研究》，廣州市科技計劃項目，100萬
【發(fā)表論文】
1. Wang Y, Wang H, Cheng B, Xia J*. Associations between triglyceride glucose index-related obesity indices and anxiety: Insights from the National Health and Nutrition Examination Survey 2007-2012. J Affect Disord. 2025 Aug 1;382:443-452.
2. Wang Y, Wu Z, Zheng Y, Wang H, Cheng B*, Xia J*. Unraveling the genetic underpinnings of mitochondrial traits and associated circulating inflammatory proteins in Alzheimer's disease: Mitochondrial HtrA2-T cell CD5 negative axis. J Alzheimers Dis. 2025 May;105(2):505-518.
3. Jiang S, Ou L, Wang Y, Su K, Chen Z, He L, Xu X, Cheng B, Xia J*, Fan Z*. CircPRMT5, a Potential Salivary Biomarker, Facilitates the Progression of Head and Neck Squamous Cell Carcinoma via the IGF2BP3-SERPINE1 Pathway. Int J Nanomedicine. 2025 Feb 5;20:1597-1613.
4. Zhang J#, Peng J#, Wang S, Wang L, Sun Y, Xia J*, Cheng B*, Hu Q*. Perilipin2-dependent lipid droplets accumulation promotes metastasis of oral squamous cell carcinoma via epithelial-mesenchymal transition. Cell Death Discov. 2025 Jan 28;11(1):30.
5. Wu S, Yang S, Ou L, Zhang H, Wang L, Feng B, Bai Z, Li W, Cheng B, Toh WS, Xia J*. Melatonin-Loaded Hydrogel Modulates Circadian Rhythms and Alleviates Oxidative Stress and Inflammation to Promote Wound Healing. ACS Appl Bio Mater. 2025 Feb 17;8(2):1607-1620.
6. Zhang Y#, Ren J#, Shen Z#, Yang J, Yang J, Lin Z, Shi X*, Zhao C*, Xia J*. BMP2 peptide-modified polycaprolactone-collagen nanosheets for periodontal tissue regeneration. Front Bioeng Biotechnol. 2025 Mar 5;13:1523735.
7. Kuang S#, Yang J#, Shen Z, Xia J*, Lin Z*. Single-Cell and Spatial Multi-Omics Analysis Reveal That Targeting JAG1 in Epithelial Cells Reduces Periodontal Inflammation and Alveolar Bone Loss. Int J Mol Sci. 2024 Dec 10;25(24):13255.
8. Yang Z#, Deng M#, Ren L#, Fan Z, Yang S, Liu S, Ren X, Gao J, Cheng B*, Xia J*. Pyroptosis of oral keratinocyte contributes to energy metabolic reprogramming of T cells in oral lichen planus via OPA1-mediated mitochondrial fusion. Cell Death Discov. 2024 Sep 17;10(1):408.
9. Cai G#, Ren L#, Yu J, Jiang S, Liu G, Wu S, Cheng B*, Li W*, Xia J*. A Microenvironment-Responsive, Controlled Release Hydrogel Delivering Embelin to Promote Bone Repair of Periodontitis via Anti-Infection and Osteo-Immune Modulation. Adv Sci (Weinh). 2024 Sep;11(34):e2403786.
10. Wu S#, Yang T#, Ma M, Fan L, Ren L, Liu G, Wang Y, Cheng B*, Xia J*, Hao Z*. Extracellular vesicles meet mitochondria: Potential roles in regenerative medicine. Pharmacol Res. 2024 Aug;206:107307.
11. Guo J#, Su K#, Wang L#, Feng B#, You X, Deng M, Toh WS, Wu J*, Cheng B*, Xia J*. Poly(p-coumaric acid) nanoparticles alleviate temporomandibular joint osteoarthritis by inhibiting chondrocyte ferroptosis. Bioact Mater. 2024 Jun 12;40:212-226.
12. Wu R#, Chen Z#, Yu J#, Lai P, Chen X, Han A, Xu M, Fan Z, Cheng B, Jiang Y*, Xia J*. A graph-learning based model for automatic diagnosis of Sj?gren's syndrome on digital pathological images: a multicentre cohort study. J Transl Med. 2024 Aug 8;22(1):748.
13. Xu X#, Pan X#, Fan Z, Xia J*, Ren X*. Lactate dehydrogenase B as a metabolism-related marker for immunotherapy in head and neck squamous cell carcinoma. Cell Signal. 2024 Aug;120:111200.
14. Li W#, Wu S#, Ren L, Feng B, Chen Z, Li Z, Cheng B*, Xia J*. Development of an Antiswelling Hydrogel System Incorporating M2-Exosomes and Photothermal Effect for Diabetic Wound Healing. ACS Nano. 2023 Nov 14;17(21):22106-22120.
15. Li Y, Ma Z, Li W, Xu X, Shen P, Zhang SE, Cheng B*, Xia J*. PDPN+ CAFs facilitate the motility of OSCC cells by inhibiting ferroptosis via transferring exosomal lncRNA FTX. Cell Death Dis. 2023 Nov 22;14(11):759.
16. Li W, Xu X, Ma Z, Shen P, Cheng B, Xia J*, Li Y*. LncRNA BANCR promotes oral squamous cell carcinoma progression via regulating Rab1A signaling. J Oral Pathol Med. 2023;52(8):727-737. doi:10.1111/jop.13463 (3.3)
17. Peng J#, Hu Q#, Wang C, Zhang J, Wang S, Wang L, Xia J*, Cheng B*. Depletion of Gr1+ myeloid cells attenuates high-fat-diet-aggravated esophageal squamous cell carcinoma in mice. Carcinogenesis. 2023;44(7):587-595. doi:10.1093/carcin/bgad047 (4.7）
18. Deng M#, Guo J#, Ling Z, Zhang C, He L, Fan Z, Cheng B*, Xia J*. KRAS mutations upregulate Runx1 to promote occurrence of head and neck squamous cell carcinoma. Mol Carcinog. 2023;62(9):1284-1294. doi:10.1002/mc.23563 (4.6)
19. Hao Z#, Liu G#, Ren L#, Liu J, Liu C, Yang T, Wu X, Zhang X, Yang L*, Xia J*, Li W*. A self-healing multifunctional hydrogel system accelerates diabetic wound healing through orchestrating immunoinflammatory microenvironment. ACS Appl Mater Interfaces. 2023 Apr 12. doi: 10.1021/acsami.2c23323. (9.5)
20. He L#, Guo J#, Fan Z, Yang S, Zhang C, Cheng B*, Xia J*. Exosomal miR-146b-5p derived from cancer-associated fibroblasts promotes progression of oral squamous cell carcinoma by downregulating HIPK3. Cell Signal. 2023;106:110635. doi: 10.1016/j.cellsig.2023.110635.
21. Hong Y, Wu J, Wu J, Xu H, Li X, Lin Z, Xia J*. Semi-Flipped Classroom-based Learning Interventions in a Traditional Curriculum of Oral Medicine: Students’ Perceptions and Teaching Achievements. BMC Med Educ. 2023 Jan 19;23(1):44. doi: 10.1186/s12909-023-04017-6.（3.2）
22. Li J#, Chen X#, Ren L, Chen X, Wu T, Wang Y, Ren X, Cheng B*, Xia J*. Type H vessel/platelet-derived growth factor receptor β+ perivascular cell disintegration is involved in vascular injury and bone loss in radiation-induced bone damage. Cell Prolif. 2023 Jan 24:e13406. doi: 10.1111/cpr.13406.（8.5）
23. Hao Z#, Ren L#, Zhang Z#, Yang Z, Wu S, Liu G, Cheng B*, Wu J*, Xia J*.A multifunctional neuromodulation platform utilizing Schwann cell-derived exosomes orchestrates bone microenvironment via immunomodulation, angiogenesis and osteogenesis. Bioact Mater. 2022 Nov 14;23:206-222. doi: 10.1016/j.bioactmat.2022.10.018. eCollection 2023 May （18.9）
24. Zhang Z#, Hao Z#, Xian C, Fang Y, Cheng B*, Wu J*, Xia J*. ?Neuro-bone tissue engineering: Multiple potential translational strategies between nerve and bone. Acta Biomater. 2022 Sep 16:S1742-7061(22)00585-2. doi: 10.1016/j.actbio.2022.09.023.（10.633）
25. Zhang C#, Ren L#, Zhang H, Yang S, Deng M, He L, Cao R, Zhao C, Xia J*. SESN1, negatively regulated by miR-377-3p, suppresses invasive growth of head and neck squamous cell carcinoma by interaction with SMAD3. Hum Cell 2022 Jul;35(4):1100-1113.
26. Wu S#, Yang Z#, Wu T, Tao X, Hong Y, Cheng B, Xia J*. Application of online learning combined with case-based discussion in oral medicine education . J Dent Educ.2022 Apr 20. doi: 10.1002/jdd.12939. Online ahead of print.
27. Lin Y, Shi M, Xiang D, Zeng P, Gong Z, Liu H, Liu Q, Chen Z, Xia J*, Chen Z*. Construction of an end-to-end regression neural network for the determination of a quantitative index sagittal root inclination. J Periodontol. 2022 Feb 12. doi: 10.1002/JPER.21-0492. Online ahead of print.
28. Ling Z#, Li W#, Hu J#, Li Y, Deng M, Zhang S, Ren X, Wu T, Xia J*, Cheng B*, Tao X*. ??Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma. Cell Death Dis. 2022 Feb 17;13(2):158. doi: 10.1038/s41419-022-04610-5.
29. Cao R#, Zhang W#, Zhang H, Wang L, Chen X, Ren X, Cheng B*, Xia J*. Comprehensive analysis of the PRDXs family in head and neck squamous cell carcinoma. Front Oncol. 2022 Mar 8;12:798483. doi: 10.3389/fonc.2022.798483. ?
30. Cao R#, Cui L#, Zhang J, Ren X, Cheng B*, Xia J*. Immune-related lncRNA classification of head and neck squamous cell carcinoma. Cancer Cell Int. 2022 Jan 15;22(1):25. doi: 10.1186/s12935-022-02450-z.
31. Li W#, Jiang L#, Wu S, Yang S, Ren L, Cheng B*, Xia J*. A shape-programmable hierarchical fibrous membrane composite system to promote wound healing in diabetic patients. Small. 2022 Jan 17:e2107544. doi: 10.1002/smll.202107544.
32. Peng J#, Hu Q#, Chen X, Wang C, Zhang J, Ren X, Wang Y, Tao X, Li H, Song M, Cheng B*, Wu T*, Xia J*. Diet-induced obesity accelerates oral carcinogenesis by recruitment and functional enhancement of myeloid-derived suppressor cells. Cell Death Dis. 2021 Oct 14;12(10):946.
33. Wang Y#, Ren X#, Li W, Cao R, Liu S, Jiang L, Cheng B*, Xia J*. SPDEF suppresses head and neck squamous cell carcinoma progression by transcriptionally activating NR4A1. Int J Oral Sci. 2021 Oct 20;13(1):33.?
34. Cao R, Liu S, Zhang J, Ren X, Chen X, Cheng B*, Xia J*. Integrative Analysis of TP53INP2 in Head and Neck Squamous Cell Carcinoma. Front Genet. 2021 Apr 9;12:630794. doi: 10.3389/fgene.2021.630794. eCollection 2021.
35. Wang Y#, Li Y#, Jiang L, Ren X, Cheng B*, Xia J*. Prognostic value of glycolysis markers in head and neck squamous cell carcinoma: a meta-analysis. ?Aging (Albany NY). 2021 Feb 26;13(5):7284-7299.
36. Li Y#, Wang Y#, Li J, Ling Z, Chen W, Zhang L, Hu Q, Wu T, Cheng B*, Wang Y*, Xia J*. Tacrolimus inhibits oral carcinogenesis through cell cycle control. Biomed Pharmacother. 2021 Jul;139: 111545.
37. Zhang C#, Wang H#, Deng M, He L, Ping F, He Y, Fan Z, Cheng B*, Xia J*. Upregulated miR?411?5p levels promote lymph node metastasis by targeting RYBP in head and neck squamous cell carcinoma. Int J Mol Med. 2021 Apr;47(4):1.?
38. Chen X, Chen L, Tan J, Zhang L, Xia J*, Cheng B*, Zhang W*.Rspo1-LGR4 axis in BMSCs protects bone against radiation-induced injury through mTOR-dependent autophagy pathway. J Cell Physiol. 2021 Jun;236(6):4273-4289. ?
39. Fan Z#, He L#, Li M#, Cao R, Deng M, Ping F, Liang X, He Y, Wu T, Tao X, Xu J, Cheng B*, Xia J*. Targeting methyltransferase PRMT5 retards the carcinogenesis and metastasis of HNSCC via epigenetically inhibiting Twist1 transcription. Neoplasia. 2020 Nov;22(11):617-629.
40. He Y#, Fan Z#, He L, Zhang C, Ping F, Deng M, Liu S, Wang Y, Cheng B*, Xia J*. Metformin combined with 4SC-202 inhibited the migration and invasion of OSCC via STAT3/Twist1. Onco Targets Ther. 2020 Oct 29;13:11019-11029.
41. Hu Q#, Peng J#, Jiang L, Li W, Su Q, Zhang J, Li H, Song M, Cheng B*, Xia J*, Wu T*. Metformin as a senostatic drug enhances the anticancer ef?cacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma . Cell Death Dis. 2020 Oct 28;11(10):925.
42. Ren L#, Chen X#, Chen X, Li J, Cheng B*, Xia J*. ?Mitochondrial Dynamics: Fission and fusion in fate determination of mesenchymal stem cells. Front Cell Dev Biol. 2020 Oct 15;8:580070.
43. Cao R#, Zhang J#, Jiang L, Wang Y, Ren X, Cheng B*, Xia J*. ?Comprehensive analysis of prognostic alternative splicing signatures in oral squamous cell carcinoma. Front oncol. 2020 Aug 28;10:1740.
44. He L#, Ping F#, Fan Z, Zhang C, Deng M, Cheng B*, Xia J*. Salivary exosomal miR-24-3p serves as a potential detective biomarker for oral squamous cell carcinoma screening. Biomed Pharmacother. 2020 Jan;121:109553.
【參編教材與論著】
1.?2024年 副主編《口腔癌、口咽癌——全生命周期診療及康復》?人民衛(wèi)生出版社?9787117370981
2.?2025年 副主編《口腔醫(yī)學思政課與專業(yè)課融合案例集萃》?人民衛(wèi)生出版社
3.?2022年 參編《口腔黏膜病學》（全國高等學校研究生規(guī)劃教材，第二版） 人民衛(wèi)生出版社?9787117216791
4.?2022年 參編《全國高級衛(wèi)生專業(yè)技術資格考試指導口腔醫(yī)學》?人民衛(wèi)生出版社?9787117318402
5.?2020年 參編《口腔基礎研究導論》?人民衛(wèi)生出版社?9787117293259
【獲獎及學術榮譽】
1.?2021年 廣東省科學技術獎二等獎《分子標志物與口腔黏膜潛在惡性疾患的演變及診療》（第1完成人）
2.?2019年 教育部科學技術進步獎二等獎《炎-癌轉化調控網絡在口腔黏膜潛在惡性疾患診療中的轉化研究》（第2完成人）
【社會兼職】
1.?中華口腔醫(yī)學會口腔醫(yī)學科研管理分會副主任委員
2.?中國醫(yī)院協會口腔醫(yī)院分會副主任委員
3.?中國老年醫(yī)學學會口腔醫(yī)學分會副會長
4.?中華口腔醫(yī)學會口腔黏膜病專委會常務委員
5.?廣東省口腔醫(yī)學會口腔黏膜病專委會主任委員
6.?廣東省醫(yī)師協會科研管理分會副主任委員
7.?廣東省口腔醫(yī)學會秘書長、常務理事
8.?廣東省研究型醫(yī)院學會監(jiān)事長
9.?《中華口腔醫(yī)學研究雜志（電子版）》副總編輯
【聯系方式】
地址：廣東省廣州市越秀區(qū)陵園西路56號
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